The Singapore Branch Centre was established in June 2015 and was officially signed and unveiled at the NTU Innovation Center by NTUiTive CEO Dr. Lim Jui of Nanyang Technological University (NTU) and the then CEO of the Eastern Centre, Mingfeng Yan. NTUiTive is responsible for managing NTU's intellectual property assets and helping to bring technologies from the lab to the market, with the aim of translating research results into economic and social benefits. NTUiTive also supports universities in their innovation and entrepreneurship efforts, promoting the next generation of entrepreneurial leaders and new business investments.

As an important layout of the Eastern Center in Southeast Asia, the Singapore Branch is constantly reviewing and researching Singapore's industrial structure and related supportive policies, helping domestic enterprises better enjoy Singapore's preferential policies, comparing cross-strait science and technology promotion policies, deepening the understanding of cross-border technology transfer issues and seeking solutions, and accelerating the pace of technology introduction and marketization of technological innovation.